Reishi vs Lion’s Mane: Which Mushroom Does What?

If you’re looking to add functional mushrooms to your routine, two names probably keep coming up: Reishi and Lion’s Mane.

They’re both adaptogens. They’re both powerful. But they do very different things.

So, what’s the difference between Reishi and Lion’s Mane? Should you take one or both? And when should you take them?

Let’s break it down.

What is Reishi?

Reishi mushroom (Ganoderma lucidum) is best known for promoting calm, better sleep, immune health and stress relief.

It’s been used for thousands of years in Eastern medicine to support the nervous system and help the body deal with physical and emotional stress.

If life feels overwhelming or your sleep isn’t cutting it, Reishi mushroom powder is the go-to.

Reishi is ideal if you want to:

• Sleep deeper and wake up more refreshed

• Manage stress and calm racing thoughts

• Support your immune system

• Improve emotional balance and recovery

To learn more, read our guide on what Reishi is good for.

What is Lion’s Mane?

Lion’s Mane mushroom (Hericium erinaceus) is your brain’s best friend.

It supports focus, memory, mental clarity and nerve health, and is used by everyone from students to professionals to anyone dealing with brain fog.

Unlike Reishi, Lion’s Mane is not calming. It’s energising in a smooth, non-stimulating way. It helps you think sharper, process quicker and stay more focused.

Lion’s Mane is ideal if you want to:

• Improve concentration and focus

• Support memory and cognitive health

• Clear brain fog

• Stay mentally alert throughout the day

For the full breakdown, check out our blog on what is Lion's Mane good for?

Key differences between Reishi and Lion’s Mane

Reishi and Lion’s Mane are both powerful, natural and safe for daily use but they target completely different systems.

Reishi works with the nervous system, helping your body wind down, manage stress and sleep better.

Lion’s Mane works with the brain and central nervous system, supporting memory, focus and neurogenesis.

You might take Reishi in the evening to relax and Lion’s Mane in the morning to switch on.

Can you take Reishi and Lion’s Mane together?

Yes and many people do.

They’re not duplicates or competitors. Reishi supports calm and recovery. Lion’s Mane supports clarity and drive. When combined, they create a balanced routine that covers both sides of daily performance.

Try this daily stack:

• Morning: 2g Lion’s Mane mushroom powder in coffee, tea or smoothie

• Evening: 2g Reishi mushroom powder in hot water or herbal tea

Use them daily, stay consistent, and you’ll likely notice more mental clarity in the day and deeper sleep at night.

Which one should you choose?

Choose Reishi if:

• You feel wired, stressed or anxious

• You’re struggling to sleep or unwind

• You want to support immune function and long-term recovery

Choose Lion’s Mane if:

• You want better focus and memory

• You’re dealing with mental fatigue or brain fog

• You need something to help you concentrate without caffeine

Or choose both for a full-spectrum wellness approach.

Why choose Fung’d Up?

Every batch of our mushroom powders is:

• 100 percent fruiting body

• Dual-extracted (10 to 1) for max potency

• Freeze-dried for freshness and bioavailability

• 2,000mg per serving, third-party tested

• Filler-free, vegan, and non-GMO

This is proper mushroom supplementation. No fluff. No grains. No compromise.

Shop now and build your daily stack

Whether you’re looking to calm the body or power up the brain — or both — we’ve got you covered.

Shop Reishi Mushroom Powder

Shop Lion’s Mane Mushroom Powder

Shop Calm and Focus Stack

FAQs: Reishi vs Lion’s Mane

Can I take Reishi and Lion’s Mane together?
Yes. Reishi powder is calming, Lion’s Mane powder is stimulating. They work well when used at different times of day.

Which is better for stress and sleep?
Reishi is best for managing stress and promoting restful sleep.

Which helps with focus and memory?
Lion’s Mane is specifically used for cognitive support and mental clarity.

Are they safe to use every day?
Yes. Both mushrooms are safe for daily use and work best when taken consistently.

What’s the best way to take them?
Stir 2g of either powder into hot water, tea or a smoothie. Take Reishi mushroom powder in the evening and Lion’s Mane mushroom powder in the morning.